Panel A: A vertical box-and-whisker plot comparing CD3 T cell counts between groups with and without immune suppression. The horizontal axis represents immune suppression status (No and Yes), and the vertical axis represents cell counts in cells per cubic millimeter. The median CD3 T cell counts are approximately 703 and 676 for the No and Yes groups, respectively. Panel B: A vertical box-and-whisker plot comparing CD4 T cell counts between groups with and without immune suppression. The horizontal axis represents immune suppression status (No and Yes), and the vertical axis represents cell counts in cells per cubic millimeter. The median CD4 T cell counts are approximately 520 and 444 for the No and Yes groups, respectively. Panel C: A vertical box-and-whisker plot comparing Naïve CD4 T cell counts between groups with and without immune suppression. The horizontal axis represents immune suppression status (No and Yes), and the vertical axis represents cell counts in cells per cubic millimeter. The median Naïve CD4 T cell counts are approximately 244 and 163 for the No and Yes groups, respectively. Panel D: A vertical box-and-whisker plot comparing CD8 T cell counts between groups with and without immune suppression. The horizontal axis represents immune suppression status (No and Yes), and the vertical axis represents cell counts in cells per cubic millimeter. The median CD8 T cell counts are approximately 104 for both the No and Yes groups. Panel E: A vertical box-and-whisker plot comparing B cell counts between groups with and without immune suppression. The horizontal axis represents immune suppression status (No and Yes), and the vertical axis represents cell counts in cells per cubic millimeter. The median B cell counts are approximately 879 and 714 for the No and Yes groups, respectively. Panel F: A vertical box-and-whisker plot comparing NK cell counts between groups with and without immune suppression. The horizontal axis represents immune suppression status (No and Yes), and the vertical axis represents cell counts in cells per cubic millimeter. The median NK cell counts are approximately 373 and 351 for the No and Yes groups, respectively.
Comparison of median lymphocyte subset counts based on immunosuppression status. Median lymphocyte subsets at 12-mo after CTTI among participants who received any immunosuppressive therapies (black circles) versus those who did not (red circles). Comparison by Mann–Whitney U test. No significant differences in the median CD3, CD4, naive CD4, CD8, B cell, or NK cell counts. Lymphocyte enumeration results for one participant who was treated with alemtuzumab were excluded. (A) Median (Q1; Q3) CD4 T cell counts (cells/mm3) for immunosuppression “no” and “yes” are 520 (343; 762) and 444 (288; 699), respectively. (B) Median (Q1; Q3) naive CD4 T cell counts (cells/mm3) for immunosuppression “no” and “yes” are 244 (133; 386) and 163 (37; 365), respectively. (C) Median (Q1; Q3) CD3 T cell counts (cells/mm3) for immunosuppression “no” and “yes” are 703 (416; 1,045) and 676 (392; 880), respectively. (D) Median (Q1; Q3) CD8 T cell counts (cells/mm3) for immunosuppression “no” and “yes” are 104 (61; 251) and 104 (37; 240), respectively. (E) Median (Q1; Q3) B cell counts (cells/mm3) for immunosuppression “no” and “yes” are 879 (689; 1,126) and 714 (351; 900), respectively. (F) Median (Q1; Q3) NK cell counts (cells/mm3) for immunosuppression “no” and “yes” are 373 (198; 944) and 351 (248; 646), respectively.