Panel A: A vertical box-and-whisker plot compares CD3 T cell counts between two groups based on PHA response. The horizontal axis represents PHA response with categories less than 5000 cpm and greater than or equal to 5000 cpm, and the vertical axis represents cell counts in cells per cubic millimeter. The plot shows median, quartiles, and outliers for each group. The p-value is 0.29, indicating no significant difference. Panel B: A vertical box-and-whisker plot compares CD4 T cell counts between the same two groups. The axes and categories are similar to Panel A. The p-value is 0.21, indicating no significant difference. Panel C: A vertical box-and-whisker plot compares naïve CD4 T cell counts between the two groups. The axes and categories are similar to previous panels. The p-value is 0.04, indicating a significant difference. Panel D: A vertical box-and-whisker plot compares CD8 T cell counts between the two groups. The axes and categories are similar to previous panels. The p-value is 0.09, indicating no significant difference.
12 -mo post-CTTI comparison of median T cell subset counts among participants with PHA response <5,000 cpm vs. >5,000 cpm. Median T cell subset counts at 12-mo after CTTI among participants with baseline PHA >5,000 cpm (black dots) versus <5,000 cpm (red dots). Comparisons by Mann–Whitney U test. No significant differences in the median CD3, CD4, or CD8 T cell counts. There is a significant difference in the median naive CD4 counts favoring baseline PHA <5,000 cmp. Flow data for one participant is excluded due to previous receipt of alemtuzumab. (A) Median (Q1; Q3) CD4 T cell counts (cells/mm3) for PHA >5,000 cpm and <5,000 cpm are 366 (294; 626) and 535 (328; 794), respectively. (B) Median (Q1; Q3) naive CD4 T cell counts (cells/mm3) for PHA >5,000 cpm and <5,000 cpm are 80 (32; 289) and 276 (120; 394), respectively. (C) Median (Q1; Q3) CD3 T cell counts (cells/mm3) for PHA >5,000 cpm and <5,000 cpm are 581 (383; 827) and 734 (407; 1,038), respectively. (D) Median (Q1; Q3) CD8 T cell counts (cells/mm3) for PHA >5,000 cpm and <5,000 cpm are 82 (28; 154) and 158 (64; 259), respectively. PHA, phytohemagglutinin.