Each graph shows the median cell counts with interquartile range for different lymphocyte subsets at 3-month intervals through 24 months post-CTTI. The x-axis represents time in months, and the y-axis represents cell counts per cubic millimeter. Panel A shows CD3 T Cell Counts, Panel B shows CD4 T Cell Counts, Panel C shows Naïve CD4 T Cell Counts, Panel D shows CD8 T Cell Counts, Panel E shows B Cell Counts, and Panel F shows NK Cell Counts. The red lines represent participants with complete HLA mismatch, while the black lines represent participants with partial HLA match. No significant differences are observed in the median counts of CD3, CD4, Naïve CD4, CD8 T cells, B cells, or NK cells between the two groups.
Longitudinal comparison of median lymphocyte subset counts after CTTI among participants with complete (6/6) HLA mismatch vs. partial (>1) match. (A–F) Median total cell counts with interquartile range for lymphocytes subsets at 3-mo intervals (y-axis) through 24 mo after CTTI (x-axis) among participants with complete HLA mismatch (6/6), shown in red, or partial HLA match (>1 allele), shown in black. Comparison by Mann–Whitney U test. No significant differences in the median CD3 (A), CD4 (B), naive CD4 (C), or CD8 (D) T cell counts. No significant differences in the median B cell (E) or NK cell (F) counts. P values for comparison of each 3-mo interval are provided in Table S1. Lymphocyte enumeration results were censored in three participants at the time they received alemtuzumab treatment at one at 3 mo and two at 12 mo, respectively.