Figure S1.
Panel A: Current traces showing responses for WT NaV1.2 and NaV1.2 IQM with each of the four FGF-A homologues during 10-pulse trains applied at 5 hertz. The x-axis represents time in milliseconds, and the y-axis represents current in nanoamperes. Panel B: Curve plots with data points and fitted curves showing averaged changes in peak sodium current during 5 hertz trains for FGF-A homologues expressed with NaV1.2 IQM (points) in comparison to channels with WT NaV1.2 (lines). The x-axis represents the pulse number in the train, and the y-axis represents the peak sodium current. Panel C: Curve plots with data points and fitted curves showing the frequency dependence of reductions in P10 fractional INa for FGF-A homologue expression with NaV1.2 IQM in comparison to that for WT NaV1.2 (lines). The x-axis represents the train frequency in hertz, and the y-axis represents the fractional sodium current.
Use-dependent changes in I Na availability mediated entirely by LTI during 10-pulse trains at different frequencies. (A) 10-pulse trains applied at 5 Hz for WT NaV1.2, and NaV1.2_IQM with each of the four FGF-A homologues. (B) Averaged changes in peak INa during 5 Hz trains for FGF-A homologues expressed with NaV1.2_IQM (point) in comparison with channels with WT NaV1.2 (lines). (C) Frequency dependence of reductions in IP10 for FGF-A homologue expression with NaV1.2_IQM in comparison with that for WT NaV1.2 (lines).