Figure 7.
Panel A: A bar graph comparing the effects of different FGF-A isoforms on inactivation at 0 mV for WT and IQM NaV1.2. The horizontal axis lists the FGF-A isoforms (FGF14A, FGF13A, FGF12A, FGF11A), and the vertical axis measures the inactivation time constant in milliseconds on a logarithmic scale. The graph includes bars for WT (in gray) and IQM (in red) with mean values and standard deviations. Individual data points are also shown. Significant differences are indicated with asterisks. Panel B: A bar graph comparing the slow recovery time constants at minus 80 millivolts for different FGF-A isoforms in association with NaV1.2 or NaV1.2 IQM. The horizontal axis lists the FGF-A isoforms (FGF14A, FGF13A, FGF12A, FGF11A), and the vertical axis measures the recovery time constant in milliseconds on a logarithmic scale. The graph includes bars for WT (in gray) and IQM (in red) with mean values and standard deviations. Individual data points are also shown. Non-significant differences are indicated with ns.
Comparisons of effects of FGF-A isoforms on WT vs. IQM Na V 1.2 inactivation onset and recovery. (A) Comparison of effect of FGF-A-isoforms on inactivation τ at 0 mV with mean ± SD for each current along with values from individual patches. Dotted line is control τi for NaV1.2 alone. (B) Comparisons of slow recovery time constants (at −80 mV) for different FGFA isoforms in association with NaV1.2 or NaV1.2_IQM. Statistical comparisons (means ± SD, N, P values) are in Table S5. **P < 0.01, ***P < 0.001, and ****P < 0.0001.