Figure 6.
Rate of recovery from inactivation of NaV1.2_IQM varies among different FGF-A homologues. (A) The paired pulse protocol on the top was used to examine the time course of recovery from inactivation for WT NaV1.2, NaV1.2+FGF14A, and then NaV1.2_IQM+FGF14A, as indicated. For NaV1.2 alone, only a single fast component of recovery is observed. For NaV1.2+FGF14A, two components of recovery can be seen with slow recovery contributing a bit more than half. For NaV1.2_IQM+FGF14A, only a single slow component of recovery is observed. (B) Averaged recovery from inactivation for NaV1.2_IQM+FGF14A is plotted along with results shown earlier for NaV1.2 alone (black line) and NaV1.2+FGF14A (solid colored line). (C–E) Similar comparisons for recovery for NaV1.2_IQM+FGF13A (C), NaV1.2_IQM+FGF12A (D), and NaV1.2_IQM+FGF11A (E). Statistical comparisons are given in Table 3. Refer to the image caption for details. Panel A: A schematic and representative current traces showing the paired pulse protocol used to examine the time course of recovery from inactivation for WT NaV1.2, NaV1.2 plus FGF14A, and NaV1.2 IQM plus FGF14A. Panel B: A recovery curve showing averaged recovery from inactivation for NaV1.2 IQM plus FGF14A, NaV1.2 alone, and NaV1.2 plus FGF14A. The horizontal axis represents recovery time in milliseconds, and the vertical axis represents the ratio of peak currents P2 divided by P1. Panel C: A recovery curve showing similar comparisons for recovery for NaV1.2 IQM plus FGF13A. The horizontal axis represents recovery time in milliseconds, and the vertical axis represents the ratio of peak currents P2 divided by P1. Panel D: A recovery curve showing similar comparisons for recovery for NaV1.2 IQM plus FGF12A. The horizontal axis represents recovery time in milliseconds, and the vertical axis represents the ratio of peak currents P2 divided by P1. Panel E: A recovery curve showing similar comparisons for recovery for NaV1.2 IQM plus FGF11A. The horizontal axis represents recovery time in milliseconds, and the vertical axis represents the ratio of peak currents P2 divided by P1.

Rate of recovery from inactivation of Na V 1.2_IQM varies among different FGF-A homologues. (A) The paired pulse protocol on the top was used to examine the time course of recovery from inactivation for WT NaV1.2, NaV1.2+FGF14A, and then NaV1.2_IQM+FGF14A, as indicated. For NaV1.2 alone, only a single fast component of recovery is observed. For NaV1.2+FGF14A, two components of recovery can be seen with slow recovery contributing a bit more than half. For NaV1.2_IQM+FGF14A, only a single slow component of recovery is observed. (B) Averaged recovery from inactivation for NaV1.2_IQM+FGF14A is plotted along with results shown earlier for NaV1.2 alone (black line) and NaV1.2+FGF14A (solid colored line). (C–E) Similar comparisons for recovery for NaV1.2_IQM+FGF13A (C), NaV1.2_IQM+FGF12A (D), and NaV1.2_IQM+FGF11A (E). Statistical comparisons are given in Table 3.

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