The first section is a diagram explaining the process of diagnosing and treating Chronic granulomatous disease (CGD). It shows the steps from clinical suspicion to improved outcomes, highlighting the role of NADPH oxidase and the respiratory burst affected in patients with CGD. The second section is a map highlighting the National Colombian cohort study area. The third section is a bar chart showing key findings with different genes and the number of patients affected by each gene. Below the bar chart, there are icons representing infections: 8 BCG complications, 5 pulmonary TB, and 17 Salmonella infections. The fourth section is a line graph showing clinical implications with higher mortality risk in XL-CGD compared to AR-CGD over time.