The diagram illustrates the stages, including shear, where cells are subjected to fluid forces; rolling, where cells roll along the endothelial surface; adhesion, where cells attach to the endothelium; and diapedesis, where cells migrate through the endothelial layer. The diagram also shows compression, where the immune cell interacts closely with the target cell, and tension, depicting the forces involved in this interaction. Traction is illustrated with the immune cell exerting force on the surrounding tissue. An inset shows a detailed view of the interaction between a T cell and a target cell, highlighting various molecular interactions and signaling pathways.