Figure S1.
Panel A: Two line graphs showing the proliferation of T cells on day 4. The graphs compare the control and patient samples for CD4 and CD8 T cells. The x-axis represents cell division, and the y-axis represents the count. The left graphs show unstimulated cells, while the right graphs show cells stimulated with anti-CD3/CD28. The control is shown in gray, and the patient is shown in red. Both CD4 and CD8 T cells show proliferation upon stimulation. Panel B: A line graph divided into two parts showing the proliferation of B cells on day 4. The x-axis represents cell division, and the y-axis represents the count. The left graph shows unstimulated cells, while the right graph shows cells stimulated with anti-IgM plus IL4 plus IL21. The control is shown in gray, and the patient is shown in red. B cells show proliferation upon stimulation.
B cell and T cell proliferation are unaffected in the patient. (A) PBMCs from the patient and healthy control were labeled with CTV and stimulated with anti-CD3/CD28 beads for 4 days. Proliferation history profiles of gated CD4+ and CD8+ T cells are shown (n = 2). (B) PBMCs from the patient and a healthy donor were labeled with CTV and stimulated with anti-IgM+IL-4+IL-21. Proliferation history profiles of gated CD19+ B cells are shown (n = 1).