Figure 3.
Panel a: A box plot with individual data points shows the distribution of log10 sjKREC levels in the blood of newborn children across different age groups. The horizontal axis represents age groups, starting from cord blood (CB) and progressing through various days and months. The vertical axis represents the log10 sjKREC levels. Each box plot displays the median, lower quartile (Q1), and upper quartile (Q3) values, with whiskers extending to the minimum and maximum values, and individual data points scattered around. Panel b: Another box plot with individual data points depicts the log10 CjKREC levels in the blood of newborn children across the same age groups. The horizontal axis represents age groups, and the vertical axis represents the log10 CjKREC levels. Each box plot shows the median, Q1, and Q3 values, with whiskers extending to the minimum and maximum values, and individual data points scattered around. Panel c: A box plot with individual data points illustrates the mean number of B cell divisions estimated by log2(CjKREC/sjKREC) across different age groups. The horizontal axis represents age groups, and the vertical axis represents the mean number of B cell divisions. Each box plot displays the median, Q1, and Q3 values, with whiskers extending to the minimum and maximum values, and individual data points scattered around. Panel d: A linear model shows coefficient estimates from a generalized linear model predicting B cell generation using variables such as rs2204985 G/G, Preterm/Term, Mode of delivery, Male sex, and Age. The horizontal axis represents coefficient estimates, and the vertical axis lists the variables. Each point represents a coefficient estimate with its corresponding p-value, indicating significance or non-significance.
B cell neogenesis in newborn children. (a) Longitudinal monitoring of sjKREC levels in the blood of newborn children showing a surge 2 mo after birth, earlier than their thymic outputs. (b) CjKREC levels in the blood of newborn children. (c) Mean number of B cell divisions estimated by log2(CjKREC/sjKREC). (d) Coefficient estimates from generalized linear model predicting B cell generation using the listed variables. Grey lines represent 95% confidence intervals from 500 bootstrap iterations. P values are from ANOVA test of the model.