Figure 2.
Panel a: A scatter plot showing the correlation between thymic output and the frequencies of various immune subpopulations. The horizontal axis represents Spearman correlation, ranging from minus 0.8 to 0.8. The vertical axis represents the negative log 10 of the adjusted p-value, ranging from 0 to 10. Several data points are plotted, with notable points labeled as Neutrophils, CD4 plus T, CD8 plus T, NK, and PDC. Neutrophils show a negative correlation, while CD4 plus T, CD8 plus T, NK, and PDC show positive correlations. A reference line is present at a Spearman correlation of 0.05. Panel b: A scatter plot showing the correlation between thymic output levels and the relative protein concentration levels of various proteins. The horizontal axis represents Spearman correlation, ranging from minus 0.8 to 0.8. The vertical axis represents the negative log 10 of the adjusted p-value, ranging from 0 to 10. Several data points are plotted, with notable points labeled as RANKL, TNFB, SCF, TWEAK, CD5, NT 3, CXCL 5, TRAIL, IL 7, IL 17A, OSM, IL 8, FGF 23, IL 6, MCP 1, MMP 10, CCL 20, CASP 8. RANKL, TNFB, SCF, TWEAK, CD5, NT 3, CXCL 5, TRAIL, IL 7, and IL 17A show positive correlations, while OSM, IL 8, FGF 23, IL 6, MCP 1, MMP 10, CCL 20, and CASP 8 show negative correlations. A reference line is present at a Spearman correlation of 0.05.
Associations between thymic output and blood immune profiles. (a) Spearman correlation between thymic output (TREC) and frequencies of 14 immune subpopulations characterized by mass cytometry. (b) Spearman correlation between thymic output levels and relative protein concentration levels (NPX) of 76 proteins characterized by Olink Target 96 inflammation panel. P values are corrected using Benjamini–Hochberg adjustment.