Figure 2.
Dysmyelopoiesis in the BM of patient III.d with SEPTIN6-related disease. (A) Mature neutrophil and two binucleate promyelocytes in the BM collected at 4 mo of age (after G-CSF). (B) Markedly enlarged mature neutrophil with hypersegmentation and surrounding erythroid precursors in the BM collected at 4 mo of age (after G-CSF). (C) Mature neutrophil with abnormal lobation and metamyelocyte in the BM aspirate collected at 9 mo of age. (D) Mature neutrophil with abnormal lobation in the BM aspirate collected at 9 mo of age. (Wright–Giemsa stains, 1,000× magnification). Refer to the image caption for details. Panel A features a fully developed neutrophil alongside two promyelocytes characterized by twin nuclei. Panel B shows a notably large, hypersegmented mature neutrophil positioned among several erythroid precursors. Panel C highlights a mature neutrophil exhibiting irregular nuclear lobation, accompanied by a metamyelocyte. Panel D provides a focused view of a mature neutrophil with abnormal nuclear shaping.

Dysmyelopoiesis in the BM of patient III.d with SEPTIN6-related disease. (A) Mature neutrophil and two binucleate promyelocytes in the BM collected at 4 mo of age (after G-CSF). (B) Markedly enlarged mature neutrophil with hypersegmentation and surrounding erythroid precursors in the BM collected at 4 mo of age (after G-CSF). (C) Mature neutrophil with abnormal lobation and metamyelocyte in the BM aspirate collected at 9 mo of age. (D) Mature neutrophil with abnormal lobation in the BM aspirate collected at 9 mo of age. (Wright–Giemsa stains, 1,000× magnification).

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