Clinical, immunologic, genetic, and therapeutic findings for IPEX syndrome within the CNE3i (Centro Nacional de Erros Inatos da Imunidade e Imunodesregulação) in Brazil. (1) Demonstrates the main clinical and geographical findings of the six IPEX patients; (2) general and advanced laboratory findings; and (3) genetics and therapeutics. SP, São Paulo; MG, Minas Gerais; PE, Pernambuco; DF, Distrito Federal; ES, Espírito Santo; IgE, immunoglobulin E; IgG immunoglobulin G; DNT, double negative T cells; IFN-SG, interferon-stimulated genes; MFI, median fluorescence intensity; BMT, bone marrow transplantation; GT, gene therapy; LFW, last follow-up.