CNE3i Year 1. Main results obtained in the first year of CNE3i (Centro Nacional de Erros Inatos da Imunidade e Imunodesregulação) in Brazil. The CNE3i is a collaborative effort of Brazilian Reference Centers for Inborn Errors of Immunity established through CoBEII, creating a technopole for innovations in the care of IEI in Brazil, located at the University of São Paulo. On the left, the drops on the Brazilian map represent reference centers, with colors indicating the number of samples included per state. On the right side, the summarized results include: i) telemedicine, ii) sequencing and analysis, iii) clinical registry, and iv) medical education and disease awareness.