Figure 1.
Panel A shows a microscopic image of endothelial cells with bright colored structures. Thin yellow fibers form a network across the cells, while magenta spots appear along these fibers. Cyan lines outline the cell borders, showing connections between cells. Panel B shows a model of protein links connecting the cells at the center. Inside each cell, filament bundles extend toward the junction. Additional proteins are shown attached near the junction, linking the internal filaments to the cell boundary.
Interplay between endothelial cell–cell junctions and the actomyosin cytoskeleton. (a) Human umbilical cord endothelial cells immunostained for VE-cadherin (cyan), F-actin (yellow), and phosphorylated myosin light chain 2 (magenta) (unpublished image). (b) Proposed model based on the current work by Mayo et al. in which near-cortical actomyosin bundles are organized by Scribble and tethered by MYO1C to VE-cadherin–based junctions. Drawing was created using Biorender.com.