On the left, AID R112H cells show disrupted interactions between components, with a focus on the AID R112H protein interfering with TET2 function. On the right, WT cells display normal interactions, with TET2 functioning properly. In AID R112H cells, the AID R112H protein is shown impairing TET2-mediated DNA demethylation at the enhancer slash promoter region of the target gene, preventing proper gene expression. In WT cells, TET2 successfully demethylate with the enhancer slash promoter region, facilitating gene expression.