Figure 1.
The diagram shows the endoplasmic reticulum (ER) at the bottom and the plasma membrane (PM) at the top. The proteins Fmp27 and Hoi1 are shown on the left side, interacting with the ER and plasma membrane. The proteins BLTP2 and FAM102A are shown on the right side, also interacting with the ER and plasma membrane. The adaptor proteins interact with a hairpin motif in the BLTP2 proteins, indicated by circles. The direction of potential lipid transport is indicated by an arrow pointing from the ER to the plasma membrane.
BLTP2 and its adaptor form a contact site between the ER and the plasma membrane. AlphaFold 3 (8) predictions of the Fmp27/Hoi1 complex and the BLTP2/FAM102A complex are shown on model bilayers representing the ER (green headgroups) and the plasma membrane (blue headgroups). The adaptor proteins interact with a hairpin motif in the BLTP2 proteins (red circles). The potential lipid transport occurs in the direction of the plasma membrane.