The diagram shows the structure of the intestinal wall with labeled regions and macrophages. The intestinal wall is divided into two layers: the lamina propria and the submucosa slash muscularis. Long-lived Tim-4 positive macrophages are present in both layers. In the lamina propria, T G F-beta 1 is present, which is key to instructing macrophage identity. In the submucosa slash muscularis, macrophages express the marker C D 163. The diagram illustrates the distinct functionality of these macrophages based on their tissue localization.