Figure 2.
Timeline of leniolisib treatment protocol with dosage escalation and monitoring tests. The timeline spans from negative three weeks to positive thirty-six weeks. The dosage escalates from ten milligrams twice daily to forty milligrams twice daily. Key events include ultrasonography of abdomen and neck, pneumology evaluation, electrocardiogram, quality of life assessment, phosphorylated S six assay, M R I of abdomen, thorax, and neck, high-resolution C T of thorax, and discontinuation of sirolimus. Extended lab tests in clinical settings and restricted lab tests at home are conducted at specified intervals. Icons represent different tests and evaluations, with colors indicating the type of test.
Leniolisib treatment protocol. Bid, twice daily; CBC complete blood cell count; INR, international normalized ratio; PCR, polymerase chain reaction; SGOT, serum glutamic-oxaloacetic transaminase; SGPT, serum glutamic-pyruvic transaminase.