Figure 1.
Panel A: Four sets of histograms are shown, each with two histograms side by side. The x-axis is labeled D H R 123 (resting) and the y-axis is labeled counts. The sets are labeled Control, X C G D, X C G D carrier, and A R-C G D. Each set shows histograms for resting and stimulated with P M A conditions. The Control set shows a peak in the stimulated condition. The X C G D set shows a peak in the resting condition. The X C G D carrier set shows two peaks in the stimulated condition. The A R-C G D set shows a peak in the resting condition and a broader peak in the stimulated condition. Panel B: A table lists D H R test limitations, related conditions with potentially normal D H R, and other causes of abnormal D H R.
Use and limitations of the dihydrorhodamine assay for diagnosis of CGD. (A) Representative histograms from DHR assay (reprinted with permission from Hematology: Basic Principle and Practice, Ed. R. Hoffman, eighth edition). The representative autosomal recessive CGD on DHR could also represent hypomorphic X-linked CGD. (B) DHR test limitations.