Figure 2.
The timeline includes the following events: 2002, c C V I D C D 21 l o; 2004, H I V C D 21 l o C D 27 l o; 2005, Tissue M B C s; 2007, S L E D N; 2008, tissue-like M B C, exhausted (H I V context); 2009, Malaria Atypical M B C; 2009–13, R A, S j S; 2011, H C V; 2014, C T L A 4; 2016, M S; 2017, Vaccination (influenza, vaccinia, Y F V); 2018, L R B A, effect of C P I, H B V; 2020, severe C O V I D 19; 2022–23, partial R A G deficiency, S T A T 5 B, S T A T 1 slash 3 G O F, T B X 21 (T-bet); 2023, Trisomy 21, c G V H D, S A R S-C o V 2 vaccine; 2024, P D C D 1 (P D 1), S O C S 1, T M E.
Timeline of key events relating to human CD21 lo B cells. MBC: memory B cells; cCVID: complex CVID; MS: multiple sclerosis; DN: double negative; SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; SjS: Sjogren’s syndrome; YFV: yellow fever vaccine; HBV: hepatitis B virus; HCV: hepatitis C virus; HIV: human immunodeficiency virus; cGVHD: chronic graft-vs.-host disease; TME: tumor microenvironment.