Identification of skin and cardiac involvement in a child with OS. (A) Diffuse erythroderma of the limbs and face at diagnosis. (B) Immunological characteristics of patient at baseline diagnosis. (C) TTE before transplantation (upper panel) and after transplantation (lower panel). Left upper part showed interventricular septum thickening in a short axis, and right upper part intraventricular acceleration in a long axis. On the left lower part, long axis showed no ventricular hypertrophy after transplantation, with normal myocardial diameters in a four-cavity view at the right lower part. (D) Skin biopsy showing a superficial derm and perivascular infiltrate consisting of histiocytes and a mixture of CD4 and CD8 lymphocytes. (E) Schematic representation of the patient’s clinical history.