Figure S2.
Panel A: A Venn diagram showing the overlap of differentially expressed genes (D E G s) in P S M B 10 W T and P S M B 10 G 209 R skin fibroblasts. The diagram includes four sets: P S M B 10 W T up, P S M B 10 G 209 R up, P S M B 10 W T down, and P S M B 10 G 209 R down, with the number of genes in each section labeled. Panel B: A vertical bar graph displaying the enrichment scores of various pathways for P S M B 10 W T. The x-axis lists pathways, and the y-axis shows enrichment scores. Panel C: A vertical bar graph similar to Panel B but for P S M B 10 G 209 R. The x-axis lists pathways, and the y-axis shows enrichment scores. Panel D: A heatmap showing the expression levels of 121 genes specific to P S M B 10 G 209 R. The heatmap is color-coded with a scale bar indicating expression levels, and genes are listed on the right side.
GO and pathway enrichment analysis for IFNγ-treated PSMB10 WT and PSMB10 G209R skin fibroblasts. (A) Venn diagram of IFNγ-induced DEGs in PSMB10 WT and PSMB10 G209R skin fibroblasts using a cutoff of |log2| >1. (B) GO analysis of DEGs with |log2| >1 for PSMB10 WT. (C) GO analysis of DEGs with |log2| >1 for PSMB10 G209R. (D) Heatmap of 121 genes with |log2| >2 specific to PSMB10 G209R.