Figure 2.
Panel shows a diagram of protein structure representation, where the left image depicts the folded three-dimensional structure of the C-terminal domain, and the right image illustrates an elastic network model with nodes representing residues connected by springs to capture structural connectivity and dynamics.
Illustration of an ENM of the C-terminal domain of the HCN4 channel. Crystal structure of CNBD from HCN4 (PDB accession no. 3U11) (left). In the network model (right), each amino acid from the structure is represented by a bead centered at its Cα atom. The covalent bonds (red lines) and all nodes within a specified cutoff distance of each other (here: 13 Å) are connected by springs (orange lines).