Figure 8.
![CR and survival analysis. (A) Aggregate CR in mice with transplanted tumors treated with ICB or with ICB + HIFi is presented. (B) Aggregate Kaplan–Meier survival curves for mice treated with vehicle, ICB, HIFi, or ICB + HIFi. ****P < 0.0001 versus ICB by the log-rank test. (C) Aggregate CR rates. Mice were treated with ICB alone (α-CTLA-4 [C] or α-PD-1 [P]) or in combination (Comb) with HIFi (1.21S9N [1] or 3.2.16 [3]) across six mouse cancer models. Refer to the image caption for details.](https://cdn.rupress.org/rup/content_public/journal/jem/223/5/10.1084_jem.20251009/1/jem_20251009_fig8.png?Expires=1778221830&Signature=2JgxSSSrw-uJD2JW3DrQ0SlzEsc7MnJKB6eGbuYcNKX6wuaN4FYEa4E212KzpABBsMz~gerd~JZl8DY6DitDM~BZzVYTNZoN8oH9oDx-G22wGf8--bJhEsUD~KNPsB0sdFh55Qni-rHKu0bQfyAk2-ipt0P8glTAfpkSZHG9F-iVJbE9A9YK3tfrY7QQuni-Hr3leGw-M0J09t5Ck7sPaA~iUq0fLMw1pLWHYTAFzJvWAghxK9SmCtGFBpQCGSGD-SMIkQIAIXxtIuzk2i0QD5xsbo-oIkhLc-abLbb1JzGQz-5IqF-YlyLePFzkBtoizxCcvWAbs3ARyPZIeYqlWA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Two graphs depict complete response and survival analysis in mice treated with immune checkpoint blockade (I C B) or I C B plus H I F inhibitors (H I F i) across various cancer models. The first graph (A) is a bar chart showing the aggregate complete response in mice with transplanted tumors. The horizontal axis represents treatment groups (I C B and I C B plus H I F i), and the vertical axis represents the number of mice. The bar for I C B plus H I F i is higher and segmented by cancer types: breast, colorectal, melanoma, and prostate. The second graph (B) is a Kaplan-Meier survival curve showing the aggregate survival rates of mice treated with vehicle, I C B, H I F i, or I C B plus H I F i. The horizontal axis represents days, and the vertical axis represents percent survival. The I C B plus H I F i group shows significantly higher survival rates, marked by four asterisks indicating P value less than 0.0001 compared to I C B alone. The table (C) summarizes aggregate complete response rates across different cancer models and treatment combinations. The table includes columns for cancer type, line, H I F i treatment, I C B treatment, and complete response rates for I C B alone and I C B plus H I F i. The data show higher complete response rates in the I C B plus H I F i group across all cancer models. All data is approximate.
CR and survival analysis. (A) Aggregate CR in mice with transplanted tumors treated with ICB or with ICB + HIFi is presented. (B) Aggregate Kaplan–Meier survival curves for mice treated with vehicle, ICB, HIFi, or ICB + HIFi. ****P < 0.0001 versus ICB by the log-rank test. (C) Aggregate CR rates. Mice were treated with ICB alone (α-CTLA-4 [C] or α-PD-1 [P]) or in combination (Comb) with HIFi (1.21S9N [1] or 3.2.16 [3]) across six mouse cancer models.