Figure 3.
![Elevated cytokine and chemokine profile in the plasma of the patient at week 17 and week 25. (A) Heatmap representing the plasma cytokine/chemokine levels normalized as Z-scores, compared to healthy control median (male pediatric heathy donors [HD], n = 11). (B) Heatmap showing the Th1 and Th2 cytokines in the patient plasma. (C) Quantification of Th1 and Th2 plasma cytokine and chemokine levels, showing a significant increase in Th2 levels at week 25 compared to week 17 (two-way ANOVA, Šídák's multiple comparisons test; *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001). Refer to the image caption for details.](https://cdn.rupress.org/rup/content_public/journal/jhi/2/3/10.70962_jhi.20250249/1/jhi_20250249_fig3.png?Expires=1777867525&Signature=3F9eoONkCir~ypTv2H27iELo7SQGrAzxqK-SJC-Mpa3dlXZ1-8~Bqbf8Vi2g6rssO8ID8NFQctzlqPqTEM3dDR8-vc8lGbBKk6ptALTXcFK0qIAI4C2MXVen3K5FSobT05aOyr0VUy61Mmp4~PcsgBq86uaGWn-5mRKDtjRJn3uqdFpDnts58P4vvbpPonuSwXWaM29mrjqQybDzaZHx-C1b8MU9vn280OeRZc24p2~k2mL7Yxbnql7lYR7qkc9UEVHXIhdo9g9PC7ej5RHIXuUPrEtbpT96WwxaQeM59YrN-t-IdJ0zoSoqqiuef35XCkdgbzlBEp3ciGJs5W2Nqw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Panel A shows heatmap plots of cytokine and chemokine Z score expression in patient plasma compared to healthy control reference values across multiple analytes. Panel B shows heatmap plots of T h 1 and T h 2 cytokine profiles in patient plasma highlighting differential immune signatures. Panel C shows box plots of T h 1 and T h 2 cytokine Z scores demonstrating increased T h 2 cytokine levels at later timepoint.
Elevated cytokine and chemokine profile in the plasma of the patient at week 17 and week 25. (A) Heatmap representing the plasma cytokine/chemokine levels normalized as Z-scores, compared to healthy control median (male pediatric heathy donors [HD], n = 11). (B) Heatmap showing the Th1 and Th2 cytokines in the patient plasma. (C) Quantification of Th1 and Th2 plasma cytokine and chemokine levels, showing a significant increase in Th2 levels at week 25 compared to week 17 (two-way ANOVA, Šídák's multiple comparisons test; *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001).