Figure 1.
Figure 1. Evolutionary adaptations of mast cell functions. Mast cell–derived mediators are critically involved in the detoxification of arthropod and reptile venoms. For example, whereas CPA3 is involved in the inhibition of Sarafotoxin 6B, MCPT4 is critical for the inhibition of Helodermin. Mast cells also contribute to the Th2-type immune response, which is critical for the prevention of helminth infections. Refer to the image caption for details.

Evolutionary adaptations of mast cell functions. Mast cell–derived mediators are critically involved in the detoxification of arthropod and reptile venoms. For example, whereas CPA3 is involved in the inhibition of Sarafotoxin 6B, MCPT4 is critical for the inhibition of Helodermin. Mast cells also contribute to the Th2-type immune response, which is critical for the prevention of helminth infections.

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