Figure 1.
Panel A shows the cells undergoing differentiation from the Stratum basale to the Stratum corneum. Spectrin is recruited to cell-cell adhesions by E-cadherin, preferentially in the S G 3 layer. Panel B provides a top-down view of this layer, revealing how spectrin and F-actin form a cortical honeycomb at cell-cell junctions. Panel C details the molecular interface where the Spectrin scaffold supports cell signaling through the activation of phosphorylated E G F R and the stabilization of the T R P V 3 ion channel.
The spectrin skeleton during keratinocyte differentiation in the epidermis. (A) Cells within the epidermis undergo progressive differentiation after they leave the stem cell compartment (stratum basale) and migrate to the cell surface (vertical arrow). Spectrin is recruited to cell–cell adhesions by E-cadherin, preferentially in the SG3 layer. (B and C) Spectrin and F-actin form a cortical honeycomb at cell–cell junctions (here drawn indicatively), which (C) supports cell signaling through activation of the EGFR (pEGFR) and stabilization of TRPV3.