O Rs for the presence of auto-Abs in the WNV groups relative to the general population, by age group. (A–D) ORs for the presence of auto-Abs in patients with WNVD relative to the general population, as determined by logistic regression, stratified for age group, for auto-Abs neutralizing different combinations of high concentrations (A) and low concentrations (B) of type I IFNs in the seven new cohorts, and for auto-Abs neutralizing different combinations of high concentrations (C) and low concentrations (D) of type I IFNs in the overall study population consisting of 13 cohorts. ORs were calculated separately for patients aged ≤65 and >65 years. Horizontal bars represent the 95% CI limits. IFN-α, auto-Abs neutralizing IFN-α2 (regardless of effects on other IFNs); IFN-ω, auto-Abs neutralizing IFN-ω; IFN-α ± ω ± β, auto-Abs neutralizing IFN-α2 and/or IFN-ω and/or IFN-β; IFN-α + ω, auto-Abs neutralizing both IFN-α2 and IFN-ω; ORs, odds ratios. ns, nonsignificant; ****P < 10⁻⁴.