Detection of auto-Abs against type I IFN by ELISA in patients with WNVD from seven new cohorts. (A) Detection, by ELISA, of auto-Abs against IFN-α2, IFN-β, and IFN-ω for the WNVD group and the two subgroups of WNVD patients: non-neuroinvasive WNVD and neuroinvasive WNVD (WNND). (B) Detection, by ELISA, of auto-Abs against IFN-α2, IFN-β, and IFN-ω in the subgroups of WNND patients: WNV encephalitis (WNE), WNV meningitis (WNM), acute flaccid paralysis (AFP), and unspecified neurological syndrome (UNS).