Figure 1.
Auto-Abs neutralizing type I IFNs in 318 WNV-infected individuals from seven new cohorts. (A) Age and sex distribution of individuals in the WNVIC, WNVF, and WNVD groups. (B) Detection of auto-Abs against IFN-α2, IFN-β, and IFN-ω by ELISA. An OD value >0.5 (dashed line) indicates a sample considered positive based on the signal typically observed for serum/plasma from healthy donors. (C) Luciferase-based neutralization assay for the detection of auto-Abs neutralizing 10 ng/ml IFN-α2, IFN-ω, or IFN-β. Neutralizing activity was defined as a luciferase signal below 15%. (D) Luciferase-based neutralization assay for detecting auto-Abs neutralizing 100 pg/ml IFN-α2 or IFN-ω, or 1 ng/ml IFN-β. Neutralizing activity was defined as a luciferase signal below 15%.

Auto-Ab s neutralizing type I IFNs in 318 WNV-infected individuals from seven new cohorts. (A) Age and sex distribution of individuals in the WNVIC, WNVF, and WNVD groups. (B) Detection of auto-Abs against IFN-α2, IFN-β, and IFN-ω by ELISA. An OD value >0.5 (dashed line) indicates a sample considered positive based on the signal typically observed for serum/plasma from healthy donors. (C) Luciferase-based neutralization assay for the detection of auto-Abs neutralizing 10 ng/ml IFN-α2, IFN-ω, or IFN-β. Neutralizing activity was defined as a luciferase signal below 15%. (D) Luciferase-based neutralization assay for detecting auto-Abs neutralizing 100 pg/ml IFN-α2 or IFN-ω, or 1 ng/ml IFN-β. Neutralizing activity was defined as a luciferase signal below 15%.

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