Figure 3.
Panel A shows a heatmap displaying the top 1,548 differentially expressed genes (D E G s) among S A P-L P D, D E-D L B C L, and non D E-D L B C L groups. The heatmap uses Z-scores for hierarchical clustering, with colors ranging from blue (low expression) to red (high expression). The top annotation bar indicates the groups: S A P-L P D in red, D E-D L B C L in blue, and non D E-D L B C L in green. The heatmap shows distinct clustering patterns separating S A P-L P D from the D L B C L subtypes. Panel B presents Gene Ontology (G O) enrichment analysis results for upregulated and downregulated genes. The x-axis represents minus log1 0 (P-value), indicating the statistical significance of each enriched biological process. Upregulated genes are enriched in processes such as m i R N A-mediated post-transcriptional gene silencing and adaptive immune response, whereas downregulated genes are enriched in processes including NK cell activation involved in immune response, sodium ion transmembrane transport, and mitotic cell cycle processes.
Comparison of transcriptomes between SAP-LPD and DLBCL. (A and B) Top 1,548 differentially expressed genes (DEGs) between 2 groups. SAP-LPD and the combined DE-DLBCL and non–DE-DLBCL group were clustered and heat-mapped using Z-scores (A). GO analysis of 552 upregulated (upper) and 996 downregulated genes (lower) was performed using Metascape (9) (B). DE, c-MYC and BCL2 DE.