The image consists of multiple panels showing various medical imaging techniques. Panel A shows brain M R I reveals focal hyperintense lesions in the frontal lobe and cerebellum. Findings indicate central nervous system involvement. Panel B shows Neck C T demonstrates clustered, enlarged lymph nodes. Appearance is consistent with nodal lymphoproliferation. Panel C shows whole-body P E T shows widespread hypermetabolic activity. Marked uptake is seen in lung, abdominal nodes, liver, and spleen. Panel D shows F D G-P E T imaging highlights systemic metabolic activity. C T identifies tonsillar enlargement and a pulmonary nodule. Panel E shows whole-body F D G-P E T demonstrates active disease burden. C T confirms cervical and para-aortic lymph node enlargement. Panel F shows that PET reveals an abnormal metabolic focus in the neck region. CT shows prominent right cervical lymphadenopathy.
Imaging findings in patients with XLP1 presenting with LPD. (A–F) Magnetic resonance imaging T2-weighted images showing abnormal enhancement in the right frontal lobe (left panel) and cerebellum (right panel) in P1 (A). Contrast-enhanced computed tomography (CT) showing multiple enlarged left cervical lymph nodes in P2 (B). An FDG-PET image of the entire body in P3 is shown in the left panel. PET-CT images show high enhancement in the right lung (upper right panel), para-aorta, and liver, with extremely high enhancement in the spleen (lower right panel) (C). An FDG-PET image of the entire body of P4 is shown in the left panel. Contrast-enhanced CT images show enlargement of the left tonsil (upper right panel) and a nodule in the left lung (lower right panel) in P4 (D). An FDG-PET image of the entire body of P5 is shown in the left panel. Contrast-enhanced CT images show enlargement of the left cervical lymph node (upper right panel) and para-aortic lymph node (lower right panel) in P5 (E). An FDG-PET image of the entire body in P6 is shown in the left panel. Contrast-enhanced CT showing enlarged right cervical lymph nodes (upper and lower right panels) (F).