Correlations of clinical and immunological parameters and predictors of continued IgGRT need. The matrix illustrates pairwise correlations among continuous variables in the study cohort (n = 28). Strong positive correlations (Spearman) were observed between total IgG and IgA, IgG1, IgG2, and pneumococcal SSA response counts above 1 mg/ml, while IgG3 showed no significant correlation with these parameters. FEV1% correlated moderately with total IgG, IgG2, and SSA counts. (A) Positive correlation >0.4 is indicated by red color, and negative correlation <−0.4 by blue color. (B) Logistic regression analysis identified SSA >1.0 mg/ml as the only significant predictor of IgGRT need, also when adjusting for age and sex yielded similar results. Diagnosis indicates years since diagnosis. Dose, weekly dose of IgGRT; INF, number of infections during the last 6 mo without IgGRT; SSA>1 and SSA>0.35, pneumococcal SSA count >1.0 mg/ml and 0.35 mg/ml, respectively. B, unstandardized regression coefficient; SE, standard error.