IgGRT reduced the burden of airway infections in patients with IgGSD. (A) Number of airway infections treated with antibiotics or infections that required hospitalization in the whole cohort of patients (n = 28) was reduced during months 12–18 on IgGRT compared with the last 6 mo without IgGRT (B) Number of infections treated with antibiotics during months 12–18 on IgGRT and during the last 6 mo without IgGRT in the subset of patients (n = 17) with the need for continuous (Cont) IgGRT. P values refer to the Wilcoxon test for paired analysis.