Cell death markers identified through ST. (A) Left: percentage of spots expressing apoptosis markers (CASP3, CASP8, BAX, BAK1, and CYCS) out of total biopsy. Middle and right: percentage of spots expressing either two or five apoptosis markers in total biopsy, epidermis only, or dermis only (respectively). (B) Left: percentage of spots expressing necroptosis markers (RIPK1 and MLKL) out of total biopsy. Middle and right: percentage of spots expressing either RIPK1 or MLKL in total biopsy, epidermis only, or dermis only (respectively). (C) Percentage of spots expressing at least one apoptotic marker (CASP3, CASP8, BAX, BAK1, or CYCS) that also express or not at least one of the ISGs (IFIT1, USP18, MX1, IFI27, IFI44L, or OAS1). (D) Percentage of spots out of total biopsy, epidermis only, and dermis only that express ZBP1. P values were calculated with a two-tailed t test. *P < 0.05; **P < 0.01.