Myeloid compartment validation. (A) Multimodal integration analysis (MIA) showing the relative expression of immune cluster from an scRNA study in each of our ST cluster. (B) Average expression and percentage of spots expressing various macrophage markers in each cluster. (C) Expression levels of CCL2 in clusters identified to be positive for monocytes (clusters 0, 1, 5, and 8). (D) Spatial location of myeloid-positive clusters (0, 1, and 8) depicted in black, yellow, and green, respectively, and the absence of those clusters depicted in white spots. (E) Deconvoluted multiplex IHC for CD16, CD163, and ACTA2.