Inflamed clusters revealed through ST. (A) ST pipeline. (B) Spatial expression and intensity levels of IFI27. (C) Percentage of spots out of total biopsy expressing at least one of the six ISGs from Fig. 3 B. (D) Relative expression of various ISGs per cluster separated by sample biopsy. (E) Spatial expression and intensity levels of IFNB1. P values were calculated with two-tailed t test. **P < 0.01.