Pathologist annotation of healthy volunteer and patient skin biopsies. (A) Lesional skin of previously characterized patient from where three biopsies were collected at different time points. (B) Partial healing of lesions with extreme scarring within 2 years of first detection. (C) Pathologist’s annotations of three healthy volunteers and three patient’s biopsies indicating different healthy and pathological states of the tissues. (D) Pathologist’s annotations pointing out signs of inflammation in the skin biopsies as indicated by the black arrows. Yellow numbers in panel D indicate the magnified areas from panel C.