Figure 4.
Cation selectivity evaluation and statistical analyses in NavAb N49K/T206A, S178TNK/TA, S178ANK/TA, and S178GNK/TAmutants. (A) The relative permeability of each cation to Na+ (PX/PNa ratios, X represents Li, K, Cs, or Ca) in NavAb N49K/T206A and each Ser178 mutant, calculated from the reversal potentials that were obtained by the ramp pulses shown in Fig. 2 C and Fig. 3, A–D. Background (BG) indicates N49K/T206A mutant without the Ser178 mutation. (B) The selectivity for K+, Cs+, and Ca2+ of BG and each Ser178 mutant.

Cation selectivity evaluation and statistical analyses in NavAb N49K/T206A, S178T NK/TA , S178A NK/TA , and S178G NK/TA mutants. (A) The relative permeability of each cation to Na+ (PX/PNa ratios, X represents Li, K, Cs, or Ca) in NavAb N49K/T206A and each Ser178 mutant, calculated from the reversal potentials that were obtained by the ramp pulses shown in Fig. 2 C and Fig. 3, A–D. Background (BG) indicates N49K/T206A mutant without the Ser178 mutation. (B) The selectivity for K+, Cs+, and Ca2+ of BG and each Ser178 mutant.

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