Displays Principal Component Analysis (PCA) plots of lymphocyte subsets, revealing distinct immunophenotypic clustering by IEI subtype and divergent T-cell patterns between patients progressing to Hodgkin versus non-Hodgkin lymphoma. (A and B) PCA scatter plots of T and B cell subset frequencies. EMRA, terminl effector memory CD45RA+; EM, effector memory; CM, central memory.