Patients with nonneoplastic/reactive LPD biopsies. The innermost ring categorizes patients based on the IUIS classification of IEI, showing that most nonneoplastic/reactive LPD requiring histological examination belong to category III (predominantly antibody deficiency). The second inner ring details specific IEI diagnoses. The third inner ring shows the identification number of each patient, reporting in parentheses the age at last follow-up; double-underlined patients are those experiencing EBV chronic replication with a viremia >1,000 copies/ml during follow-up. The fourth inner ring specifies the overall histologic features of nonneoplastic/reactive LPD, reporting in parentheses the age at biopsy; EBER-negative LPD are displayed in a lighter shade, distinguishing them from EBER-positive LPD, which retain the same color shade as their corresponding internal classification rings (except for P14, P15, P18, P19, and P31, for which EBER expression was not available). A darker shade is reserved to reverted diagnosis upon histologic reassessment. The outermost ring reports the type of lymphoma developed by the corresponding patient of the third inner ring; the age at lymphoma biopsy is reported in parentheses. EBER-negative lymphomas are displayed in a lighter shade, distinguishing them from EBER-positive lymphomas, which retain the same color shade as their corresponding internal classification rings.