CLDN15 permeability profile is comparable between full and reduced CLDN15 models. (A) Single-channel cation and anion conductance of the CLDN15^WT full model. (B) Single-channel cation and anion conductance of CLDN15^WT reduced model Replicas 1 and 2. (C) I–V plots of the full model CLDN15^WT for ±0.1, ±0.2, and ±0.4 V. (D) I–V plots of the reduced model CLDN15^WT at ±0.2 V and ±0.4 V.