Role of γδ T cell–derived IL-17A during chemotherapy. CD3⁺ TCR δ⁺ or CD3⁺ TCR δ⁻ T cells from WT mice (A), CD3⁺ TCR δ⁺ T cells from IL-17A^−/− (B), or IL-1R1^−/− (C) mice were injected intratumorally into MCA205-bearing WT mice (A–C) or IL-17A^−/− mice (D) 2 d after PBS or DX treatment. Tumor sizes are plotted as mean ± SEM for five mice/group. Experiments were repeated two to three times with similar results. *, P < 0.05; **, P < 0.01.