Clinical phenotype of the proband. (A) Brain MRI showing FLAIR hyperintensities in the deep periventricular white matter. (B) Kidney biopsy showing V and II class glomerulonephritis with C1q deposition. (C) Chilblain lesions. (D) Timeline of treatments and clinical signs. DH, dermohypodermitis; MLN, membranous lupus nephritis; MMF, mycophenolate mofetil; NS, nephrotic syndrome; RNB, renal biopsy; SLE, systemic lupus erythematosus. Created with BioRender (https://BioRender.com).