Relationships between Krt14, Krt15, and Krt10 in mouse back skin (complement to Fig. 2 ). (A and B) UMAP of saline-treated, tape stripping sensitized mouse back skin highlighting Krt15 levels (green) and (A) Krt14 or (B) Krt10 levels (red) across Seurat clusters. (C) sc expression of Krt15 mapped against Krt14 levels in 4,806 keratinocytes in the mouse back skin dataset. (D) Distribution of Krt14 and Krt15 expression across all keratinocytes in the dataset. (E) Distribution of Krt15, Krt14, and Krt10 expression in cells exhibiting increasing levels of basal score signature genes (composite scores defined in Materials and methods). (F) Analysis of the average keratin expression level across 7 Seurat clusters matching keratinocyte signatures in the back skin dataset. Krt14 (red, circle), Krt15 (green, square), and Krt10 (blue, triangle) assessed per cluster. Clusters are sorted on the x axis from those showing highest basal score to highest differentiation score. Seurat cluster matching the highest level of G2/M composite score is highlighted. (G) Expression of G2/M composite score relative to Krt14 and Krt15 levels across keratinocytes in mouse sensitized back skin. (H) Comparison of linear pairwise expression between type I and type II keratins Krt14/Krt5 (red, R² = 0.65), Krt10/Krt1 (blue, R² = 0.19), and Krt15/Krt5 (green, R² = 0.50) across all keratinocytes in the mouse back skin dataset. (H′) Heatmap summarizing Pearson’s (r) correlations between type I and type II keratins across the dataset.