Cell–cell interaction analysis reveals key discrepancies between TB-diseased and control lung niches. (A) Top 20 ligand–receptor (L–R) pairs from MultiNichenet analysis highlighting putative interaction pairs with upregulated interactions in TB-negative lung compared with TB-diseased lung. (B) Top 20 ligand–receptor (L–R) pairs from MultiNichenet analysis highlighting putative interaction pairs differentially communicating in TB-diseased lungs. (C) Summary of top 200 interactions in TB-diseased and TB-negative/control lungs by the number of interactions between each cell pair. Cartoons on the right of each heatmap show the suggested major modes of interactions in each condition. (D) Circos plots of significant interaction pairs in TB-diseased lungs from LIANA, where sender and receiver cell types in each condition are clustered to reflect similar patterns.