Expression and physiological functions of TMEM63s across human cell types. (A) Recent studies (referring to Table 1) reported the physiological and pathological roles of TMEM63A, TMEM63B, and TMEM63C in tissue-specific cell types, revealing their functions as mechanosensors and osmosensors. (B) Normalized transcript per million (nTPM) of TMEM63A, TMEM63B, and TMEM63C from Human Protein Atlas (HPA) database are displayed by heat map.