Figure 1.
The evolutionarily conserved mechanically gated ion channels of OSCA/TMEM63 protein family.(A) Phylogenetic tree of OSCA/TMEM63 proteins across model plants A. thaliana, invertebrate D. melanogaster, mammal Mus musculus, and Homo sapiens. For plant orthologs, OSCA are systematically named as OSCA1.1–8, OSCA2.1–5, OSCA3.1, and OSCA4.1, of which the numerical prefix indicates different subfamilies. There is only one copy of TMEM63 in Drosophila. Mammal orthologs, for both mouse and human, include three members of TMEM63A, TMEM63B, and TMEM63C. Sequences were aligned in Mega11 by maximum likelihood method. (B) Topology diagram of OSCA/TMEM63 with major transmembrane helices and structural components highlighted. The residues in cytoplasmic domain between TM0 and TM1 are named as IL1; those between TM2 and TM3 are named as IL2. Suffix “H” indicates α helix and “β” indicates β sheet.

The evolutionarily conserved mechanically gated ion channels of OSCA/TMEM63 protein family. (A) Phylogenetic tree of OSCA/TMEM63 proteins across model plants A. thaliana, invertebrate D. melanogaster, mammal Mus musculus, and Homo sapiens. For plant orthologs, OSCA are systematically named as OSCA1.1–8, OSCA2.1–5, OSCA3.1, and OSCA4.1, of which the numerical prefix indicates different subfamilies. There is only one copy of TMEM63 in Drosophila. Mammal orthologs, for both mouse and human, include three members of TMEM63A, TMEM63B, and TMEM63C. Sequences were aligned in Mega11 by maximum likelihood method. (B) Topology diagram of OSCA/TMEM63 with major transmembrane helices and structural components highlighted. The residues in cytoplasmic domain between TM0 and TM1 are named as IL1; those between TM2 and TM3 are named as IL2. Suffix “H” indicates α helix and “β” indicates β sheet.

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