Conformational transition from closed to open around the MIDAS and ADMIDAS. States 1–8 are shown superimposed and shaded on their carbons and metal ions over a grayscale from closed state 1 (white) to open state 8 (dark gray). Key side chain, RGD Asp, and β1-α1 loop backbone atoms are shown in sticks. The remaining backbone is shown as a wormlike trace, with the α1 and merged α1/α1′ helices thicker. Distances show overall movements. MIDAS and ADMIDAS metal ions are spheres with states numbered for the ADMIDAS. Some side chains and the Met-335 carbonyl group are circled, and their oxygens are shown in orange or red to tell them apart. Nitrogens are shown in blue.